2004 24:4469–77.īlanco-Centurion C, Gerashchenko D, Salin-Pascual RJ, Shiromani PJ. Expression of a poly-glutamine-ataxin-3 transgene in orexin neurons induces narcolepsy-cataplexy in the rat. 1995 41:52.īeuckmann CT, Sinton CM, Williams SC, Richardson JA, Hammer RE, Sakurai T, Yanagisawa M. A new DRB1*1202 allele (DRB1*12022) found in association with DQA1*0102 and DQB1*0602 in two black narcoleptic subjects.
Narcolepsy type 1 as an autoimmune disorder: evidence, and implications for pharmacological treatment. Recent advances in treatment for narcolepsy. Effects of hypocretin/orexin cell transplantation on narcoleptic-like sleep behavior in rats. Westchester: American Academy of Sleep Medicine 2014.Īrias-Carrion O, Murillo-Rodriguez E. The international classification of sleep disorders. 1989 12:487–94.Īmerican Academy of Sleep Medicine. Automobile accidents in patients with sleep disorders. In this chapter, we will discuss the biology of the orexin system, the clinical aspects of narcolepsy, and examples of translation from basic science research into clinical practice in the field of narcolepsy. Orexin replacement is likely to be a future treatment option for orexin-deficient narcolepsy patients.
Knowledge of how therapeutic agents used to treat narcolepsy act and the underlying neuronal mechanisms come from studies in animal models. Animal models have been used in the pharmacologic study of narcolepsy. Also, there is information on the association between respiratory regulation and the orexin system. Recent advances have shown the value of finding decreased cerebrospinal fluid orexin in the diagnosis of human narcolepsy, and the role of the human leucocyte antigen (HLA) gene in the pathogenesis of narcolepsy. A deficient endogenous orexin system due to neuronal loss of orexin neurons in the hypothalamus is the main pathophysiological mechanism for narcolepsy in humans. Narcolepsy is characterized by excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic and hypnopompic hallucination, and disturbed nocturnal sleep.
0 kommentar(er)
